The Scandinavian Simvastatin Survival Study was a study done in 1994 to understand the role of simvastatin in particular and statins in general on the lipid levels in diseased individuals. In the Scandinavian Simvastatin Survival Study , patients with history of MI (80%) or angina (20%) and raised serum CH level (> 212 mg/dl) were […]
Hyperlipoproteinaemia is the increase in lipoproteins in the blood. Hyperlipoproteinaemia can be of the following two types: (i) Secondary Hyperlipoproteinaemia: associated with diabetes, myxoedema, nephrotic syndrome, chronic alcoholism, drugs (corticosteroids, oral contraceptives, Beta blockers) etc. (ii) Primary Hyperlipoproteinaemia: due to: (a) A single gene defect: is familial and called ‘monogenic’ or genetic Hyperlipoproteinaemia. (b) Multiple
Liver secretes very low density lipoproteins (VLDL) containing mainly TG and some CHE into blood. VLDL is acted upon by endothelial lipoprotein lipase in the same way as on Chy and the fatty acids pass into adipose tissue and muscle; the remnant called intermediate density lipoprotein (IDL) now contains more CHE than TG. About half
Lipid transport occurs in the plasma as lipoproteins after getting associated with several apoproteins; plasma lipid concentrations are dependent on the concentration of lipoproteins. The core of lipoprotein globules consists of triglycerides (TGs) or cholesteryl esters (CHE) while the outer polar layer has phospholipids, free cholesterol (CH) and apoproteins. The lipoproteins have been divided into
Genetics and hereditary factors play an important role in the incidence of bacteria helicobacter pylori infection. Moreover it has been found that when there is recurring infection it may lead to serious complications like stomach cancer. In common cases the clinical presentation of bacteria helicobacter pylori involves peptic ulcers and gastritis. This kind of infection
Pyloroplasty and Vagotomy are surgical methods that are applied for the resection or partial severing of a part of the gastrointestinal system; and it is used for the treatment of perforated duodenal ulcers. There are many controversies, regarding the decision for pyloroplasty and vagotomy for resolving the defect. Therefore, many studies have been conducted and
The finney pyloroplasty is performed when there is excessive bleeding in the duodenum and the surgery requires a longer incision on the duodenum. Thus the finney pyloroplasty is ideally used for the closure of fibrotic duodenum. In certain cases where there is excessive scarring of the pylorus canal, heineke mikulicz pyloroplasty cannot be performed and
According to various experiments based on post mortem studies it has been revealed that heineke mikulicz pyloroplasty is useful in the treatment of pyloric stenosis. This procedure has been thus named after the associated persons Walter Hermann Heineke and Jan Mikulicz radecki for the by treatment of pyloric stenosis. In the heineke mikulicz pyloroplasty, the
When a newborn baby is showing signs of projectile vomiting, the pediatrician may conduct a test in order to diagnose pyloric stenosis in newborns. An ultrasound will be useful in confirming the occurrence of pyloric stenosis in newborns. It has been found that pyloric stenosis is the most common form of gastrointestinal obstruction found in
According to statistical reports it has been found that congenital hypertrophic pyloric stenosis is very common in the US as well as in the Asian population. In fact every pediatrician is bound to come across at least one case with congenital hypertrophic pyloric stenosis. The incidence of this disease is more in male children as
