Lovenox is an anticoagulant commonly in use. It is the commercial name for Enoxaparin and is produced by Sanofi-Aventis. Lovenox is treatment of deep venous thrombosis ( DVT) and Pulmonary embolism. It is recently been prescribed tretment as well as prevention of acute coronary syndromes like unstable angina. Lovenox is a low molecular weight heparin used to prevent blood […]
Anxiety is a common symptom that many feel on certain occasions like facing an exam or addressing a speech or even visiting the doctor or getting a procedure being done. Drugs that decrease anxiety are called as anxiolytic medications. They are commonly prescribed by doctors for a variety of problems like insomnia, panic attacks and
Amiodarone is a complex antiarrhythmic agent (predominantly class III) that shares at least some of the properties of each of the other three Vaughn-Williams classes of antiarrhythmics. Atrial fibrillation is a common arrhythmia in the intensive care unit (ICU) setting. The mainstay of therapy is rate control, with beta-blockers being the first-line agent. However, frequently
Agents that can be considered as Amiodarone alternatives for the treatment of atrial fibrillation depend upon the patient’s cardiac history, as individuals with reduced left ventricular systolic function are especially prone to the proarrhythmic effects of certain antiarrhythmic agents. Some commonly used Amiodarone alternatives include ibutilide, dofetilide, and sotalol. Strong consideration should be made for
Ibutilide prolongs repolarization by inhibition of the delayed rectifier potassium current (Ikr) and by selective enhancement of the slow inward sodium current. Ibutilide is a newer anti arrhythmic used in particularly for patients suffering from atrial fibrillation not responding to the commonly used medications. Ibutilide is efficacious in the termination of atrial fibrillation (AF) and flutter with both single and repeated intravenous infusions. It
Dofetilide prolongs the action potential and QTC in a concentration-related manner. Dofetilide exerts its effects solely by inhibition of the rapid component of the delayed rectifier potassium current Ikr. Dofetilide has stronger evidence in its favor for acute cardioversion of atrial fibrillation than for maintenance thereafter, according to a meta-analysis. It can be given to
Human albumin is obtained from pooled human plasma; 100 ml of 20% human albumin solution is the osmotic equivalent of about 400 ml of fresh frozen plasma or 800 ml of whole blood. It can be used without regard to patient’s blood group and does not interfere with coagulation. Unlike whole blood or plasma, human
Polyvinylpyrrolidone PPV is a synthetic polymer (average MW 40,000) used as a 3.5% solution. It is used as a volume or plasma expander and is used to increase the intravascular compartment fluid. It interferes with blood grouping and cross-matching and is a histamine releaser. Polyvinylpyrrolidone ppv is slowly excreted by kidney and small amounts by
The fibrates (isobutyric acid derivatives) primarily activate lipoprotein lipase which is a key enzyme in the degradation of VLDL resulting in lowering of circulating TGs. This effect is of the fibrates is exerted through paroxisome proliferator-activated receptor ci (PPARc) that is a gene transcription regulating receptor expressed in liver, fat and muscles. Activation of PPARct enhances
Fenofibrate is another 2nd generation prodrug fibric acid derivative which has greater HDL-CH raising and greater LDL-CH lowering action than other fibrates. Hence Fenofibrate may be more appropriate as an adjunctive drug in subjects with raised LDL-CH levels in addition to raised TG levels. No rise in LDL-CH has been observed in patients with high
