Degraded gelatin polymer or Polygeline is a polypeptide with average MW 30,000 which exerts oncotic pressure similar to albumin and is not that antigenic.
Hypersensitivity reactions are rare with Polygeline, but should be watched for.
It is a colloid, which is a type of fluid heavier than the commonly used fluids that are called crystalloids.
Polygeline does not interfere with grouping and cross- matching of blood arid remains stable for three years. It is not metabolized in the body; excreted slowly by the kidney.
Expansion of plasma volume with Polygeline lasts for 12 hours. It is more expensive than dextran.
It can also be used for priming of heart-lung and dialysis machines.
Hypersensitivity reactions like flushing, rigor, urticaria, wheezing and hypotension can occur with Polygeline.
Other colloids commonly available are HAEMACCEL and SERACCEL which come as a 500 ml vac. (as 3.5% solution in balanced electrolyte medium).