Polygeline

Degraded gelatin polymer or Polygeline is a polypeptide with average MW 30,000 which exerts oncotic pressure similar to albumin and is not that antigenic.

Hypersensitivity reactions are rare with Polygeline, but should be watched for.

It is a colloid, which is a type of fluid heavier than the commonly used fluids that are called crystalloids.

Polygeline does not interfere with grouping and cross- matching of blood arid remains stable for three years. It is not metabolized in the body; excreted slowly by the kidney.

Expansion of plasma volume with Polygeline lasts for 12 hours. It is more expensive than dextran.

It can also be used for priming of heart-lung and dialysis machines.

Hypersensitivity reactions like flushing, rigor, urticaria, wheezing and hypotension can occur with Polygeline.

Other colloids commonly available are HAEMACCEL and SERACCEL which come as a 500 ml vac. (as 3.5% solution in balanced electrolyte medium).

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