Hydralazine Dose is affected by its pharmacokinetics. Hydralazine is well absorbed orally, and is subjected to first pass metabolism in liver. The chief metabolic pathway is acetylation which exhibits a bimodal distribution in the population there are slow and fast acetylators. Bioavailability is higher in slow acetylators, but these patients are more prone to develop […]
Hydralazine or Dihydralazine is a directly acting arteriolar vasodilator with little action on venous capacitance vessels; reduces t.p.r. It causes greater reduction of diastolic than systolic BP. Reflex compensatory mechanisms are evoked which cause tachycardia, increase in c.o. and renin release — increased aldosterone — Na and water retention. The disproportionate cardiac stimulation appears to
Reserpine is an alkaloid from the roots of Rauwofia serpentina (sarpgandha) indigenous to India which has been used in ‘Ayurvedic’ medicine for centuries. The pure alkaloid was isolated in 1955 and later formed to act by causing CA and 5-HI depletion. Reserpine was a popular antihypertensive of the late 1950s and early 1960s, but is
Guanethidine is an adrenergic neural blocker that has been used for treating hypertension. Guanethidine is a polar guanidine compound which is taken up into the adrenergic nerve endings by active amine transport, and has three important facets of action: (a) It displaces NA (noradrenaline) from storage granules stoichiometrically. (b) Inhibits nerve impulse coupled release of
Antihypertensive drug refers to the important class of drugs used for treating blood pressure. They have remarkably improved in the last 50 years. Different classes of drugs have received prominence with passage of time in this period. Before 1950 hardly any effective and tolerated antihypertensive drug was available. Veratrum and Sod. thiocyanate could lower BP,
Antihypertensives are drugs used to lower BP in hypertension. Hypertension is a very common disorder, particularly past middle age and hence antihypertensives are very commonly employed drugs in medical practice.. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The cut off manometric reading between normotensives
Cardiac catherization is an investigation technique, that is used in order to confirm the presence of a suspected heart disease. It is also useful when the medical practitioner is trying to quantify the severity of the disease and its consequent effect on the heart. When a patient is suffering from shortness of breath and showing
There is a common notion, that a PCI stenting is used for treatment of various ailments associated with the artery. But actually there are various types of stents and they are applied in the urinary tract, urethral or prostatic stent, vascular and peripheral stents are being applied in the treatment of various diseases. The term
A heart cath procedure is described as a surgical procedure that is performed under a local anesthetic; and it involves the insertion of a catheter into a valve or vessel of the heart. There are many applications of the heart cath method. When the heart cath is performed in order to insert the catheter into
The main function of the pulmonary artery is to carry blood from the heart to the lungs. The pulmonary artery arises from the base of the right ventricle and ends in the lungs. This artery is commonly referred to as the pulmonary trunk or main pulmonary artery. Unlike all other arteries, the pulmonary artery is
