Hyperlipoproteinaemia is the increase in lipoproteins in the blood. Hyperlipoproteinaemia can be of the following two types:

(i) Secondary Hyperlipoproteinaemia: associated with diabetes, myxoedema, nephrotic syndrome, chronic alcoholism, drugs (corticosteroids, oral contraceptives, Beta blockers) etc.

(ii) Primary Hyperlipoproteinaemia: due to:

(a) A single gene defect: is familial and called ‘monogenic’ or genetic Hyperlipoproteinaemia.

(b) Multiple genetic, dietary and physical activity related causes: ‘polygenic’ or multi- factorial.

Statin uptake and metabolism and should be taken into account for combining with them for treatment of hyperlipidaemia.

Use Statins are the first choice drugs for primary hyperlipidaemia with raised LDL and total CH levels, with or without raised IC levels (Type ha, JIb, V), as well as for secondary (diabetes, nephrotic syndrome) hypercholesterolaemia.

Efficacy of statins in reducing raised LDL-CH associated mortality and morbidity is now well established.

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