Acute pyelonephritis pathophysiology

Acute pyelonephritis pathophysiology results when there is bacterial infection in the body that affects the renal parenchyma. It has been found that in most cases, the bacterial infection does not present any symptoms. In case of acute infection, the disease causing bacteria interact with the host factors in many ways. The bacteria belong to the genus”Escheresia Coli” and are the major cause of kidney infections.

According to medical texts, about the acute pyelonephritis pathophysiology, 70-90% of infections are undetected. On the other hand, 21 to 54 % of the individuals suffer from the various adverse effects of the infection. The E.Coli may colonize in the bladder, gut, mouth, vagina and they may also affect the polymorphonuclear leukocytes. An acute pyelonephritis pathophysiology report reveals that the E Coli bacteria contain mannose resistant adhesions that facilitate in the proves of attaching themselves to the epithelial lining in renal parenchyma.

Some of the toxins released by the bacteria include alpha hemolysin, cytotoxic necrotizing factor-1, autotransporter toxin and cytolethal distending toxin. The acute pyelonephritis pathophysiology it is found that in certain pregnant women with prior UTI infections, or coming from lower socio economic status, there is a high incidence of the infection. The acute pyelonephritis infection may occur during the second and third trimester. It may cause serious complications for the fetus as many neonatal deaths have been associated with this condition.

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