Minoxidil is a powerful vasodilator, the pattern of action resembling hydralazine, i.e. direct relaxation of arteriolar smooth muscle with little effect on venous capacitance. Marked vasodilatation elicits strong compensatory reflexes: increased renin release and proximal tubular Na’ reabsorption — marked Na and water retention — oedema and CHF may occur; increased sympathetic activity – palpitation, […]

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