Hydralazine

Hydralazine or Dihydralazine is a directly acting arteriolar vasodilator with little action on venous capacitance vessels; reduces t.p.r. It causes greater reduction of diastolic than systolic BP. Reflex compensatory mechanisms are evoked which cause tachycardia, increase in c.o. and renin release — increased aldosterone — Na and water retention. The disproportionate cardiac stimulation appears to […]