Guanethidine

Guanethidine is an adrenergic neural blocker that has been used for treating hypertension. Guanethidine is a polar guanidine compound which is taken up into the adrenergic nerve endings by active amine transport, and has three important facets of action: (a) It displaces NA (noradrenaline) from storage granules stoichiometrically. (b) Inhibits nerve impulse coupled release of […]