The fibrates (isobutyric acid derivatives) primarily activate lipoprotein lipase which is a key enzyme in the degradation of VLDL resulting in lowering of circulating TGs. This effect is of the fibrates is exerted through paroxisome proliferator-activated receptor ci (PPARc) that is a gene transcription regulating receptor expressed in liver, fat and muscles. Activation of PPARct enhances […]

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