Dofetilide

Dofetilide prolongs the action potential and QTC in a concentration-related manner. Dofetilide exerts its effects solely by inhibition of the rapid component of the delayed rectifier potassium current Ikr. Dofetilide has stronger evidence in its favor for acute cardioversion of atrial fibrillation than for maintenance thereafter, according to a meta-analysis. It can be given to […]