Angiotensin Converting Enzyme Inhibitors or ACE Inhibitors

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The ACE inhibitors are one of the first choice drugs in all grades of essential as well as renovascular hypertension (except those with bilateral renal artery stenosis). Most patients require relatively lower doses (enalapril 2.5—10 mg/day or equivalent) which are well tolerated. Used alone Angiotensin Converting Enzyme Inhibitors control hypertension in —50% patients, and addition […]

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Prazosin Side Effects

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Prazosin Side Effects are rare at lower dosage that is commonly used. Prazosin is generally well tolerated at low doses. One of the most common prazosin side effects is Postural hypotension. Apart from postural hypotension related symptoms (to which tolerance frequently develops), other side effects are headache, drowsiness, dry mouth, weakness, palpitation, nasal blockade, blurred vision and

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Prazosin Nightmares

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Prazosin Nightmares is a distressing side effects of prazosin, an antihypertensive in common use. Prazosin is a Alpha antagonist that is used to reduce or control the blood pressure of a hypertensive patient. The drug can some times cause frightning nightmares which is called as Prazosin Nightmares . The nightmares that occur with Prazosin are a rare side effect that

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Prazosin

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Prazosin is a prototype selective a antagonist dilates both resistance and capacitance vessels; effect on the former predominating. The haemodynamic effects—reduction in t.p.r. and mean BP with only slight decrease in venous return and c.o. are similar to that produced by a direct acting vasodilator. However, there is little reflex cardiac stimulation and renin release

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Hydralazine side effects

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Hydralazine side effects are frequent and mainly due to vasodilatation. 1. The most common hydralazine side effects are facial flushing, conjunctival injection, throbbing headache, dizziness, palpitation, nasal stuffiness, fluid retention, edema, CHF. 2. Angina and MI may be precipitated in patients with coronary artery disease are Hydralazine side effects that can be life threatening. 3.

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Hydralazine Dose

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Hydralazine Dose is affected by its pharmacokinetics. Hydralazine is well absorbed orally, and is subjected to first pass metabolism in liver. The chief metabolic pathway is acetylation which exhibits a bimodal distribution in the population there are slow and fast acetylators. Bioavailability is higher in slow acetylators, but these patients are more prone to develop

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Hydralazine

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Hydralazine or Dihydralazine is a directly acting arteriolar vasodilator with little action on venous capacitance vessels; reduces t.p.r. It causes greater reduction of diastolic than systolic BP. Reflex compensatory mechanisms are evoked which cause tachycardia, increase in c.o. and renin release — increased aldosterone — Na and water retention. The disproportionate cardiac stimulation appears to

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Reserpine

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Reserpine is an alkaloid from the roots of Rauwofia serpentina (sarpgandha) indigenous to India which has been used in ‘Ayurvedic’ medicine for centuries. The pure alkaloid was isolated in 1955 and later formed to act by causing CA and 5-HI depletion. Reserpine was a popular antihypertensive of the late 1950s and early 1960s, but is

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Guanethidine

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Guanethidine is an adrenergic neural blocker that has been used for treating hypertension. Guanethidine is a polar guanidine compound which is taken up into the adrenergic nerve endings by active amine transport, and has three important facets of action: (a) It displaces NA (noradrenaline) from storage granules stoichiometrically. (b) Inhibits nerve impulse coupled release of

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